Metagenomics, gene discovery and the ideal biocatalyst
نویسندگان
چکیده
منابع مشابه
Metagenomics, gene discovery and the ideal biocatalyst.
With the rapid development of powerful protein evolution and enzyme-screening technologies, there is a growing belief that optimum conditions for biotransformation processes can be established without the constraints of the properties of the biocatalyst. These technologies can then be applied to find the "ideal biocatalyst" for the process. In identifying the ideal biocatalyst, the processes of...
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Metagenomics is a term that describes both a field of scientific research and a set of techniques that enables the culture-independent analysis of a microbial community in any environmental sample. The field has grown exponentially in the last 10 to 15 years; allowing researchers unparalleled access to the “uncultured majority” of our microbial counterparts in our environments and closer to hom...
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Transaminase enzymes have significant potential for the sustainable synthesis of amines using mild aqueous reaction conditions. Here a metagenomics mining strategy has been used for new transaminase enzyme discovery. Starting from oral cavity microbiome samples, DNA sequencing and bioinformatics analyses were performed. Subsequent in silico mining of a library of contiguous reads built from the...
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The use of enzymes in industrial catalysis continues to grow because of the considerable advantages of natural catalytic systems. The need for enantiomerically pure fine chemicals and the movement away from chemically burdened technologies will drive the acceptance of enzyme-assisted processes. New technologies for enzyme discovery and optimization have enabled the application of enzymes in har...
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1 Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands, Centre for Molecular and Biomolecular Informatics, Radboud University Medical Centre, Nijmegen, Netherlands, Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia, Max Planck Tandem Group in Computational Biology, Universidad de los Andes, Bogotá, Colombia, Center for Genome Sciences and ...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2004
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst0320298